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In fact, over the past couple of decades, aberrant intracellular ROS levels and the cell's inability to clear the oxidants have been implicated in various diseases, including cancer, neurodegenerative disease, cardiovascular disease, diabetes, and gastrointestinal disease (Box 2)

The oxidative stress induced by excessive intracellular iron levels and insufficient GSH contributes to the lethal accumulation of lipid peroxides, ultimately resulting in ferroptosis of cancer cells [153]

K., Guo, M

[14] For N-acetylcysteine, studies have used doses between 600 mg and 1,800 mg daily, with 600 mg twice daily being a commonly studied regimen